Obesity increases the frequency of macrophages in tumors and induces their expression of the immune checkpoint protein PD-1 - a target of cancer immunotherapies. The findings, published June 12 in the journal Nature, provide a mechanistic explanation for how obesity can contribute to both increased cancer risk and enhanced responses to immunotherapy.
This makes monitoring proteins and their molecular changes - the study of proteomics - beneficial for drug discovery, disease diagnosis and health management.
Alzheimer's disease is the most common cause of dementia. Of the 944,000 people living with dementia in the UK, 60-80% have Alzheimer's.