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Acquisition of Icosavax completed

World Pharma News - Mon, 02/19/2024 - 11:00
AstraZeneca announced today the successful completion of the acquisition of Icosavax, Inc., a US-based clinical-stage biopharmaceutical company focused on developing differentiated, high-potential vaccines using an innovative, protein virus-like particle (VLP) platform. As a result of the acquisition, Icosavax has become a subsidiary of AstraZeneca, with operations in Seattle, US.

UIC research helps create new antibiotic that evades bacterial resistance

World Pharma News - Fri, 02/16/2024 - 11:00
Scientists at the University of Illinois Chicago and Harvard University have developed an antibiotic that could give medicine a new weapon to fight drug-resistant bacteria and the diseases they cause.

The antibiotic, cresomycin, described in Science, effectively suppresses pathogenic bacteria that have become resistant to many commonly prescribed antimicrobial drugs.

First patient randomized in AskBio Phase II gene therapy trial for congestive heart failure

World Pharma News - Thu, 02/15/2024 - 11:00
Bayer AG and Asklepios BioPharmaceutical, Inc. (AskBio), a gene therapy company wholly owned and independently operated as a subsidiary of Bayer AG, announced that the first patient has been randomized in GenePHIT (Gene PHosphatase Inhibition Therapy), a Phase II trial of AB-1002 (also known as NAN-101) for the treatment of congestive heart failure (CHF).

Clinical trial shows rheumatoid arthritis drug could prevent disease

World Pharma News - Wed, 02/14/2024 - 11:00
A drug used to treat rheumatoid arthritis could also prevent the disease in individuals deemed to be at risk.

Results from a Phase 2b clinical trial, published in The Lancet by researchers led by King's College London, provides hope for arthritis sufferers after it was shown that the biologic drug abatacept reduces progression to this agonising chronic inflammatory disease.

Cleveland Clinic research reveals unique tumor-related bacteria tied to young-onset colorectal cancer

World Pharma News - Tue, 02/13/2024 - 11:00
New research from global health system Cleveland Clinic has mapped changes in tumor-related bacteria to uncover potential new strategies to combat the rise of young-onset colorectal cancer (CRC) in people under the age of 50.

The research reveals differences in tumor-related bacteria associated with young-onset colorectal cancer.

Vaccine shows promise against CMV, a virus that causes birth defects

World Pharma News - Mon, 02/12/2024 - 11:00
An experimental mRNA vaccine against human cytomegalovirus (CMV), a common virus that can infect babies during pregnancy, elicited some of the most promising immune responses to date of any CMV vaccine candidate, according to a study by Weill Cornell Medicine investigators.

Using cancer's strength to fight against it

World Pharma News - Fri, 02/09/2024 - 11:00
Scientists at the UC San Francisco (UCSF) and Northwestern Medicine may have found a way around the limitations of engineered T cells by borrowing a few tricks from cancer itself.

By studying mutations in malignant T cells that cause lymphoma, they zeroed in on one that imparted exceptional potency to engineered T cells. Inserting a gene encoding this unique mutation into normal human T cells made them more than 100 times more potent at killing cancer cells without any signs of becoming toxic.

Chapman scientists code ChatGPT to design new medicine

World Pharma News - Thu, 02/08/2024 - 11:00
Generative artificial intelligence platforms, from ChatGPT to Midjourney, grabbed headlines in 2023. But GenAI can do more than create collaged images and help write emails - it can also design new drugs to treat disease.

Today, scientists use advanced technology to design new synthetic drug compounds with the right properties and characteristics, also known as "de novo drug design." However, current methods can be labor-, time-, and cost-intensive.

Vividion Therapeutics starts Phase I clinical trial in advanced solid and hematologic tumors with oral STAT3 inhibitor

World Pharma News - Wed, 02/07/2024 - 11:00
Vividion Therapeutics, Inc. (Vividion), announced that it has initiated dosing of patients in a Phase I clinical trial evaluating VVD-130850, an investigational oral STAT3 inhibitor for the treatment of advanced solid and hematologic tumors. Vividion is a biopharmaceutical company, and a wholly owned and independently operated subsidiary of Bayer AG,

MSU researchers find early, promising glioblastoma treatment

World Pharma News - Tue, 02/06/2024 - 11:00
A team of Michigan State University scientists has unveiled a potential game-changer in the fight against glioblastoma, the most common and currently incurable form of brain cancer.

A team of Michigan State University scientists has unveiled a potential game-changer in the fight against glioblastoma, the most common and currently incurable form of brain cancer.

The American Cancer Society and Pfizer announce a $15 million, three-year initiative to bridge the gap in cancer care disparities

World Pharma News - Mon, 02/05/2024 - 11:00
The American Cancer Society (ACS) and Pfizer Inc. (NYE: PFE) today announced the launch of "Change the Odds: Uniting to Improve Cancer Outcomes™," a three-year initiative to bridge the gap in cancer care disparities. Through $15 million in funding from Pfizer, the initiative aims to improve health outcomes in medically underrepresented communities across the United States by enhancing awareness of and access to cancer screenings, clinical trial opportunities, and patient support and comprehensive navigation.

Verve Halts Trial for Lead Gene Editing Program Due to Safety Concerns

Biospace news - Sun, 02/04/2024 - 02:00
Verve Halts Trial for Lead Gene Editing Program Due to Safety Concerns 4/2/2024

Ipsen Inks Potential $900M Deal with Sutro for Global Rights to Preclinical ADC

Biospace news - Sun, 02/04/2024 - 02:00
Ipsen Inks Potential $900M Deal with Sutro for Global Rights to Preclinical ADC 4/2/2024

Vertex Pushes Oral Drug into Phase III Kidney Disease Trial, Eyes Accelerated Approval

Biospace news - Sun, 02/04/2024 - 02:00
Vertex Pushes Oral Drug into Phase III Kidney Disease Trial, Eyes Accelerated Approval 4/2/2024

Roivant Posts Phase II Eye Disease Win for TYK2 Drug, Plans Pivotal Program

Biospace news - Sun, 02/04/2024 - 02:00
Roivant Posts Phase II Eye Disease Win for TYK2 Drug, Plans Pivotal Program 4/2/2024

Teva, Viatris Again Challenge J&J Patent for Schizophrenia Drug with Appeals Court Win

Biospace news - Sun, 02/04/2024 - 02:00
Teva, Viatris Again Challenge J&J Patent for Schizophrenia Drug with Appeals Court Win 4/2/2024

Eiger Files for Bankruptcy, Plans to Shutter Operations After Difficult Year

Biospace news - Sun, 02/04/2024 - 02:00
Eiger Files for Bankruptcy, Plans to Shutter Operations After Difficult Year 4/2/2024

Gritstone Fails Cancer Vaccine Trial, Plans Phase III and Public Offering

Biospace news - Sun, 02/04/2024 - 02:00
Gritstone Fails Cancer Vaccine Trial, Plans Phase III and Public Offering 4/2/2024

Cheating death: How cancer cells escape

World Pharma News - Fri, 02/02/2024 - 11:00
Cell death is fundamental to life and, thus, healthy aging. In the realm of cellular biology, ferroptosis (a form of programmed cell death) has emerged not only as a focal point of research for its potential in eliminating cancer cells, but also its role in a plethora of other diseases, including neurodegenerative diseases such as Alzheimer's disease, eye diseases such as Retinitis pigmentosa and age-related macular degeneration, as well as ischemia, cardiovascular disease, liver disease, acute kidney injury and inflammation.

US prescription drug prices are 2.78 times those in other wealthy nations

World Pharma News - Thu, 02/01/2024 - 11:00
Prescription drug prices in the U.S. are significantly higher than in other nations, with prices in the U.S. averaging 2.78 times those seen in 33 other nations, according to a new RAND report.

The gap between prices in the U.S. and other countries is even larger for brand-named drugs, with U.S. prices averaging 4.22 times those in comparison nations.