In research published in JAMA Neurology on April 7, UF researchers studied Medicare claims data of older adults with Type 2 diabetes to assess the association among glucagon-like peptide-1 receptor agonists, or GLP-1RAs, sodium-glucose cotransporter-2 inhibitors, or SGLT2is, and the risk of Alzheimer's disease and related dementias.
The treatment involved creating nerve cells (neurons) derived from embryonic stem cells and transplanting them into the brains of 12 Parkinson's patients.
The research, published in Proceedings of the National Academy of Sciences, highlights the new drug's potential as a treatment option for conditions like schizophrenia, where psychedelics are not prescribed for safety reasons.
Authors Maria Marco, professor with the Department of Food Science and Technology, and Lei Wei, a postdoctoral researcher in Marco's lab, looked at what happens during fermentation - specifically, how the metabolites in sauerkraut compared to those in raw cabbage.
The research was led by Prof. HU Hai, who holds dual appointments as professor at the Hangzhou Institute of Medicine (HIM) of the Chinese Academy of Sciences (CAS), and Chief Physician at Zhejiang Cancer Hospital, in collaboration with Prof. LUO Manli from Sun Yat-Sen University and Prof. LI Hongde from HIM.
After decades of trial and error, a promising new target is emerging - the Lyme bacterial protein CspZ, which the bacteria use to evade detection from the body's immune system.
Restoring blood flow rapidly is decisive and can save lives. But paradoxically, it can also lead to further damage to the blood vessels in the brain.
Use of statins conveyed an additional protective effect for people with low LDL-C, specifically those with blood levels less than 1.8 mmol/L (<70 mg/dL), reducing their risk of dementia even further.
A groundbreaking study conducted by researchers at Hokkaido University has unveiled a novel class of zwitterionic phospholipids capable of significantly enhancing the functional delivery of mRNA. The study was published in the Advanced Science.
The investigators' findings were published in the peer-reviewed Journal of Clinical Investigation.
The potential target, the FLT1 gene, contributes to the production of a protein, fetal hemoglobin, whose presence is already known to improve the lifespan of people with sickle cell disease.