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GSK signs agreement to support pandemic preparedness in Europe

World Pharma News - Mon, 08/01/2022 - 10:00
GSK plc (LSE/NYSE: GSK) announced it had signed a framework contract with the European Commission's (EC) Health Emergency Preparedness and Response Authority (HERA) for the reservation of future production and supply of 85 million doses of its pandemic influenza vaccine Adjupanrix [pandemic influenza vaccine (split virion, inactivated, adjuvanted)].

Disparities in United States COVID-19 vaccine distribution

World Pharma News - Fri, 07/29/2022 - 10:00
When reports showed COVID-19 vaccination rates were lower among racial/ethnic minority groups, most discussions focused on mistrust and misinformation among these populations or their reduced access to health care facilities. But new research from University of California San Diego and collaborating institutions has identified an additional barrier to equity: whether or not each health care facility actually received and administered vaccines.

New needle-free nasal vaccine shows promise for COVID-19

World Pharma News - Thu, 07/28/2022 - 10:00
New research shows that a needle-free mucosal bacteriophage (phage) T4-based COVID-19 vaccine is effective against SARS-CoV-2 infection. The findings were published in mBio, an open access journal of the American Society for Microbiology.

In recent years, the Food and Drug Administration authorized mRNA- and adenovirus-based SARS-CoV-2 vaccines.

Pfizer and BioNTech advance COVID-19 vaccine strategy with study start of next-generation vaccine candidate based on enhanced spike protein design

World Pharma News - Wed, 07/27/2022 - 10:00
Pfizer Inc. (NYSE: PFE) and BioNTech SE (Nasdaq: BNTX) today announced that the companies have initiated a randomized, active-controlled, observer-blind, Phase 2 study to evaluate the safety, tolerability, and immune response of an enhanced COVID-19 mRNA-based vaccine candidate at a 30 µg dose level.

Scientists develop new biomimetic formulation for treating glioblastoma

World Pharma News - Tue, 07/26/2022 - 10:00
Glioblastoma multiforme (GBM) is an aggressive brain cancer with a poor prognosis and few treatment options. New and effective approaches for GBM treatment are therefore urgently needed.

Based on observation of elevated lactate in resected GBM, researchers from the Institute of Process Engineering (IPE) of the Chinese Academy of Sciences and Shenzhen Second People's Hospital have developed a

SARS-CoV-2 hijacks nanotubes between neurons to infect them

World Pharma News - Mon, 07/25/2022 - 10:00
COVID-19 often leads to neurological symptoms, such as a loss of taste or smell, or cognitive impairments (including memory loss and concentration difficulties), both during the acute phase of the disease and over the long term with "long COVID" syndrome. But the way in which the infection reaches the brain was previously unknown. Scientists from Institut Pasteur and CNRS laboratories have used state-of-the-art electron microscopy approaches to demonstrate that SARS-CoV-2 hijacks nanotubes, tiny bridges that link infected cells with neurons.

Demonstration of a potent, universal coronavirus monoclonal antibody therapy for all COVID-19 variants

World Pharma News - Fri, 07/22/2022 - 10:00
The SARS-CoV-2 that causes COVID-19 has killed 6.3 million people worldwide since 2019, painfully highlighting the vulnerability of humanity to novel coronaviruses.

Researchers discovered a neutralizing monoclonal antibody that potentially acts as a potent universal coronavirus therapy against SARS-CoV-2 and all its variants of concern, including Beta, Gamma, Delta, Epsilon and Omicron.

AstraZeneca to acquire TeneoTwo and its clinical-stage T-cell engager

World Pharma News - Thu, 07/21/2022 - 10:00
AstraZeneca announced an agreement to acquire TeneoTwo, Inc. (TeneoTwo)i, including its Phase I clinical-stage CD19/CD3 T-cell engager, TNB-486, currently under evaluation in relapsed and refractory B-cell non-Hodgkin lymphoma(1).

The acquisition of TNB-486 aims to accelerate the development of this potential new medicine for B-cell haematologic malignancies, including diffuse large B-cell lymphoma and follicular lymphoma.

Anti-inflammatory compound shows potential in treating patients with severe COVID-19

World Pharma News - Wed, 07/20/2022 - 10:00
An anti-inflammatory compound may have the potential to treat systemic inflammation and brain injury in patients with severe COVID-19 and significantly reduce their chances of death, according to a new study from UTHealth Houston and other institutions.

Versanis Taps Biotech Veteran Pruzanski to Drive Obesity Drug Forward

Biospace news - Wed, 07/20/2022 - 02:00
On Wednesday, Versanis appointed Intercept Pharmaceuticals veteran Mark Pruzanski as chairman and chief executive officer, and John Maraganore has taken a seat on the board.

CAMP4 Brings $100M to Target the Dark Side of the Genome with regRNA Platform

Biospace news - Wed, 07/20/2022 - 02:00
CAMP4 Therapeutics raised another $100 million in financing to advance its approach into the “dark side of the genome” and drive two therapeutics into clinical trials next year.

VBL Becomes Latest Casualty in Heated Battle to Solve Ovarian Cancer

Biospace news - Wed, 07/20/2022 - 02:00
VBL's ofra-vec candidate was primarily evaluated on its ability to improve PFS and OS in study participants—and delivered disappointing results for both measures.

Women of Color in Biopharma: Overcoming Barriers and Fighting for a Seat at the Table

Biospace news - Wed, 07/20/2022 - 02:00
Women of color continue to be trailblazers in the life science industry, proving that they can be just as, if not more, successful than their peers - even if it isn’t always easy.

Battle of the Patents: Daiichi Sankyo, Seagen, Alnylam, CureVac, Pfizer, BioNTech & Moderna

Biospace news - Wed, 07/20/2022 - 02:00
The LPN technology used in the mRNA COVID-19 vaccines has been the target of numerous patent challenges. Here's a look at recent biopharma patent disputes.

Biogen Axes Schizophrenia Program, Touts Potential of Next Alzheimer's Drug

Biospace news - Wed, 07/20/2022 - 02:00
At Biogen's quarterly conference call, outgoing CEO Michel Vounatsos emphasized a strong balance sheet and 10 exciting late-stage programs. The company also raised its 2022 guidance.

Merck’s Keytruda Backslides After Failed Head and Neck Cancer Trial

Biospace news - Wed, 07/20/2022 - 02:00
Merck's Phase III trial studying Keytruda (pembrolizumab) for unresected locally advanced head and neck squamous cell carcinoma (HNSCC) failed to meet the primary endpoint.

Money on the Move: Auron, Frontera, Immunocore and More Reel in New Funds

Biospace news - Wed, 07/20/2022 - 02:00
Auron Therapeutics reels in $48 million to identify novel AI-based cancer targets, Frontera scoops up $160 million for AAV gene therapy and tech manufacturing and MMI scores $75 million for robotic microsurgery.

5 Job Interview Techniques That Actually Work

Biospace news - Wed, 07/20/2022 - 02:00
Finding a new job can be a daunting task. From updating your resume to preparing for interviews, there are a lot of moving parts. To help, here are five interview techniques that actually work.

Jazz’s Toehold on Sleep Market Slips with Tentative Avadel FDA Approval

Biospace news - Wed, 07/20/2022 - 02:00
Avadel and Jazz Pharma, a leader in treating sleep disorders, are locked in a patent dispute. If it receives final FDA approval, Avadel's Lumryz could challenge Jazz's market dominance.

Roche Inks Potential $1B AAV Vector Deal with Avista for Eye Disease

Biospace news - Wed, 07/20/2022 - 02:00
Avista Therapeutics inked a partnership deal with Swiss pharma giant Roche to develop AAV gene therapy vectors for eye diseases.